This 10 frame cine loop (created with the fusion software) shows the accumulation in the tibia of 18F- from the time of entering the injection site in the arm until it is collected in the fracture.

The first six frames are each ten seconds long and the material is seen entering the wounded area after 40 seconds. The next four frames are 30 seconds each and by the end of the first three minutes, it is apparent that most of the 18F- has accumulated at the fracture site.

The cine loop is first played a few times at slow speed, then many times at a faster speed.

Being able to visualize where and how rapidly the 18F- is being deposited helps the orthopedic surgeon to determine if the bone remodeling is progressing toward healing as expected. If not, some revision to the surgery must be done to promote healing.